Tertiary Alkylamines as Nucleophiles in Substitution Reactions at Heteroaromatic Halide During the Synthesis of the Highly Potent Pirinixic Acid Derivative 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic Acid (YS-121)

YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid. It is a potent dual PPARα/γ-agonist, as well as a potent dual 5-LO/mPGES-1-inhibitor. Additionally, recent studies showed an anti-inflammator...

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Detalles Bibliográficos
Autores principales: Gabler, Matthias, Schubert-Zsilavecz, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264330/
https://www.ncbi.nlm.nih.gov/pubmed/22143571
http://dx.doi.org/10.3390/molecules161210013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264330/
https://www.ncbi.nlm.nih.gov/pubmed/22143571
http://dx.doi.org/10.3390/molecules161210013

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