Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manne...

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Detalles Bibliográficos
Autores principales: Ichibakase, Tomonori, Nakatsu, Masato, Nakajima, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264331/
https://www.ncbi.nlm.nih.gov/pubmed/21694667
http://dx.doi.org/10.3390/molecules16065008
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author Ichibakase, Tomonori
Nakatsu, Masato
Nakajima, Makoto
author_facet Ichibakase, Tomonori
Nakatsu, Masato
Nakajima, Makoto
author_sort Ichibakase, Tomonori
collection PubMed
description Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.
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spelling pubmed-62643312018-12-10 Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate Ichibakase, Tomonori Nakatsu, Masato Nakajima, Makoto Molecules Article Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner. MDPI 2011-06-17 /pmc/articles/PMC6264331/ /pubmed/21694667 http://dx.doi.org/10.3390/molecules16065008 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ichibakase, Tomonori
Nakatsu, Masato
Nakajima, Makoto
Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title_full Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title_fullStr Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title_full_unstemmed Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title_short Enantioselective Evans-Tishchenko Reduction of β-Hydroxyketone Catalyzed by Lithium Binaphtholate
title_sort enantioselective evans-tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264331/
https://www.ncbi.nlm.nih.gov/pubmed/21694667
http://dx.doi.org/10.3390/molecules16065008
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AT nakajimamakoto enantioselectiveevanstishchenkoreductionofbhydroxyketonecatalyzedbylithiumbinaphtholate

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