Cargando…

Synthesis of Quinolin-2-one Alkaloid Derivatives and Their Inhibitory Activities against HIV-1 Reverse Transcriptase

Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Pi, Gu, Qiong, Liu, Wei, Zou, Jian-Feng, Ou, Yang-Yong, Luo, Zhong-Yong, Zeng, Jian-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264335/ https://www.ncbi.nlm.nih.gov/pubmed/21900867 http://dx.doi.org/10.3390/molecules16097649

Ejemplares similares

Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors
por: BHARDWAJ, Nivedita, et al.
Publicado: (2020)

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase
por: Yanvarev, D.V., et al.
Publicado: (2016)

Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity
por: Valadão, Ana Luiza Chaves, et al.
Publicado: (2015)

HIV-1 reverse transcriptase inhibitory activity of Aerva lanata plant extracts
por: Gujjeti, Rajendra Prasad, et al.
Publicado: (2014)

Inhibitory effect of aqueous dandelion extract on HIV-1 replication and reverse transcriptase activity
por: Han, Huamin, et al.
Publicado: (2011)

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
por: Schauer, Grant, et al.
Publicado: (2013)

A Laccase with Antiproliferative and HIV-I Reverse Transcriptase Inhibitory Activities from the Mycorrhizal Fungus Agaricus placomyces
por: Sun, Jian, et al.
Publicado: (2012)

Reverse transcriptases prime DNA synthesis
por: Zabrady, Matej, et al.
Publicado: (2023)

Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
por: Penta, Ashok, et al.
Publicado: (2013)

Correction: Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
por: Penta, Ashok, et al.
Publicado: (2013)

HIV-1 CRF08_BC mutants resistant to reverse transcriptase inhibitors
por: Wu, Hao, et al.
Publicado: (2014)

Total synthesis of pyrrolo[2,3-c]quinoline alkaloid: trigonoine B
por: Nishiyama, Takashi, et al.
Publicado: (2021)

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
por: Zheng, Xunhai, et al.
Publicado: (2014)

Novel Thiazolidin-4-ones as Potential Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
por: Petrou, Anthi, et al.
Publicado: (2019)

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases
por: Álvarez, Mar, et al.
Publicado: (2017)

NMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
por: Thammaporn, Ratsupa, et al.
Publicado: (2015)

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
por: Warren, Kylie, et al.
Publicado: (2009)

Docking study of HIV-1 reverse transcriptase with phytochemicals
por: Seal, Abhik, et al.
Publicado: (2011)

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
por: Smith, Steven J., et al.
Publicado: (2014)

Asymmetric conformational maturation of HIV-1 reverse transcriptase
por: Zheng, Xunhai, et al.
Publicado: (2015)

Architecture of an HIV-1 reverse transcriptase initiation complex
por: Larsen, Kevin P., et al.
Publicado: (2018)

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
por: Rhee, Soo-Yon, et al.
Publicado: (2016)

Approved HIV reverse transcriptase inhibitors in the past decade
por: Li, Guangdi, et al.
Publicado: (2022)

A Laccase with HIV-1 Reverse Transcriptase Inhibitory Activity from the Broth of Mycelial Culture of the Mushroom Lentinus tigrinus
por: Xu, LiJing, et al.
Publicado: (2012)

Novel indole and quinoline alkaloids from Melodinus yunnanensis
por: Cai, Xiang-Hai, et al.
Publicado: (2011)

Intramolecular Cyclization During Bromination of the Quinoline Alkaloid Haplophyllidine
por: Ubaidullaev, A. U., et al.
Publicado: (2022)

Implications of telomerase reverse transcriptase in tumor metastasis
por: Zou, Yongkang, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of 2-Thioxopyrimidin-4(1H)-one Derivatives as Potential Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
por: Khalifa, Nagy M., et al.
Publicado: (2014)

Utilization of a Deoxynucleoside Diphosphate Substrate by HIV Reverse Transcriptase
por: Garforth, Scott J., et al.
Publicado: (2008)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2008)

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance
por: Acosta-Hoyos, Antonio J., et al.
Publicado: (2010)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2009)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
por: Masuda, Takao, et al.
Publicado: (2022)

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
por: Kirby, Thomas W., et al.
Publicado: (2023)

Antitumor and HIV-1 Reverse Transcriptase Inhibitory Activities of a Hemagglutinin and a Protease Inhibitor from Mini-Black Soybean
por: Ye, Xiu Juan, et al.
Publicado: (2011)

A Novel Laccase with Potent Antiproliferative and HIV-1 Reverse Transcriptase Inhibitory Activities from Mycelia of Mushroom Coprinus comatus
por: Zhao, Shuang, et al.
Publicado: (2014)

In Vitro Antioxidant Properties, HIV-1 Reverse Transcriptase and Acetylcholinesterase Inhibitory Effects of Traditional Herbal Preparations Sold in South Africa
por: Ndhlala, Ashwell R., et al.
Publicado: (2010)

A sorghum xylanase inhibitor-like protein with highly potent antifungal, antitumor and HIV-1 reverse transcriptase inhibitory activities
por: Lin, Peng, et al.
Publicado: (2013)

Detection and differentiation of Schmallenberg, Akabane and Aino viruses by one-step multiplex reverse-transcriptase quantitative PCR assay
por: Lee, Ji-Hye, et al.
Publicado: (2015)

A reverse transcriptase ribozyme
por: Samanta, Biswajit, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_60fnfssh1pl9alud2576rd9rs8