Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal e...

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Detalles Bibliográficos
Autores principales: Souto, Augusto Lopes, Tavares, Josean Fechine, da Silva, Marcelo Sobral, Diniz, Margareth de Fátima Formiga Melo, de Athayde-Filho, Petrônio Filgueiras, Filho, José Maria Barbosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264344/
https://www.ncbi.nlm.nih.gov/pubmed/21989312
http://dx.doi.org/10.3390/molecules16108515
Descripción
Sumario:Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.

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