Cargando…

Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation

We present three versatile solid-supported scaffold building blocks based on the (deoxy)cholic acid framework and decorated with handles for further derivatization by modern ligation techniques such as click chemistry, Staudinger ligation or native chemical ligation. Straightforward procedures are p...

Descripción completa

Detalles Bibliográficos
Autores principales: Verzele, Dieter, Figaroli, Sara, Madder, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264362/
https://www.ncbi.nlm.nih.gov/pubmed/22157580
http://dx.doi.org/10.3390/molecules161210168
_version_ 1783375478976937984
author Verzele, Dieter
Figaroli, Sara
Madder, Annemieke
author_facet Verzele, Dieter
Figaroli, Sara
Madder, Annemieke
author_sort Verzele, Dieter
collection PubMed
description We present three versatile solid-supported scaffold building blocks based on the (deoxy)cholic acid framework and decorated with handles for further derivatization by modern ligation techniques such as click chemistry, Staudinger ligation or native chemical ligation. Straightforward procedures are presented for the synthesis and analysis of the steroid constructs. These building blocks offer a new, facile and shorter access route to bile acid-peptide conjugates on solid-phase with emphasis on heterodipodal conjugates with defined spatial arrangements. As such, we provide versatile new synthons to the toolbox for bile acid decoration.
format Online
Article
Text
id pubmed-6264362
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62643622018-12-10 Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation Verzele, Dieter Figaroli, Sara Madder, Annemieke Molecules Article We present three versatile solid-supported scaffold building blocks based on the (deoxy)cholic acid framework and decorated with handles for further derivatization by modern ligation techniques such as click chemistry, Staudinger ligation or native chemical ligation. Straightforward procedures are presented for the synthesis and analysis of the steroid constructs. These building blocks offer a new, facile and shorter access route to bile acid-peptide conjugates on solid-phase with emphasis on heterodipodal conjugates with defined spatial arrangements. As such, we provide versatile new synthons to the toolbox for bile acid decoration. MDPI 2011-12-07 /pmc/articles/PMC6264362/ /pubmed/22157580 http://dx.doi.org/10.3390/molecules161210168 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Verzele, Dieter
Figaroli, Sara
Madder, Annemieke
Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title_full Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title_fullStr Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title_full_unstemmed Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title_short Shortcut Access to Peptidosteroid Conjugates: Building Blocks for Solid-Phase Bile Acid Scaffold Decoration by Convergent Ligation
title_sort shortcut access to peptidosteroid conjugates: building blocks for solid-phase bile acid scaffold decoration by convergent ligation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264362/
https://www.ncbi.nlm.nih.gov/pubmed/22157580
http://dx.doi.org/10.3390/molecules161210168
work_keys_str_mv AT verzeledieter shortcutaccesstopeptidosteroidconjugatesbuildingblocksforsolidphasebileacidscaffolddecorationbyconvergentligation
AT figarolisara shortcutaccesstopeptidosteroidconjugatesbuildingblocksforsolidphasebileacidscaffolddecorationbyconvergentligation
AT madderannemieke shortcutaccesstopeptidosteroidconjugatesbuildingblocksforsolidphasebileacidscaffolddecorationbyconvergentligation