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Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives

A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluor...

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Detalles Bibliográficos
Autores principales: Limban, Carmen, Marutescu, Luminita, Chifiriuc, Mariana Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264380/
https://www.ncbi.nlm.nih.gov/pubmed/21900862
http://dx.doi.org/10.3390/molecules16097593
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author Limban, Carmen
Marutescu, Luminita
Chifiriuc, Mariana Carmen
author_facet Limban, Carmen
Marutescu, Luminita
Chifiriuc, Mariana Carmen
author_sort Limban, Carmen
collection PubMed
description A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy and tested for their interaction with bacterial cells in free and adherent state. The anti-pathogenic activity was correlated with the presence of one iodine, bromide or fluorine, and two or three chloride atoms on the N-phenyl substituent of the thiourea moiety, being significant especially on Pseudomonas aeruginosa and Staphylococcus aureus strains, known for their ability to grow in biofilms. Our results demonstrate the potential of these derivatives for further development of novel anti-microbial agents with antibiofilm properties.
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spelling pubmed-62643802018-12-10 Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives Limban, Carmen Marutescu, Luminita Chifiriuc, Mariana Carmen Molecules Article A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy and tested for their interaction with bacterial cells in free and adherent state. The anti-pathogenic activity was correlated with the presence of one iodine, bromide or fluorine, and two or three chloride atoms on the N-phenyl substituent of the thiourea moiety, being significant especially on Pseudomonas aeruginosa and Staphylococcus aureus strains, known for their ability to grow in biofilms. Our results demonstrate the potential of these derivatives for further development of novel anti-microbial agents with antibiofilm properties. MDPI 2011-09-06 /pmc/articles/PMC6264380/ /pubmed/21900862 http://dx.doi.org/10.3390/molecules16097593 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Limban, Carmen
Marutescu, Luminita
Chifiriuc, Mariana Carmen
Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title_full Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title_fullStr Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title_full_unstemmed Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title_short Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives
title_sort synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264380/
https://www.ncbi.nlm.nih.gov/pubmed/21900862
http://dx.doi.org/10.3390/molecules16097593
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