Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans

A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the or...

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Autores principales: He, Jingwei, Söderling, Eva, Österblad, Monica, Vallittu, Pekka K., Lassila, Lippo V. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264393/
https://www.ncbi.nlm.nih.gov/pubmed/22113583
http://dx.doi.org/10.3390/molecules16119755
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author He, Jingwei
Söderling, Eva
Österblad, Monica
Vallittu, Pekka K.
Lassila, Lippo V. J.
author_facet He, Jingwei
Söderling, Eva
Österblad, Monica
Vallittu, Pekka K.
Lassila, Lippo V. J.
author_sort He, Jingwei
collection PubMed
description A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
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spelling pubmed-62643932018-12-10 Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans He, Jingwei Söderling, Eva Österblad, Monica Vallittu, Pekka K. Lassila, Lippo V. J. Molecules Article A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition. MDPI 2011-11-23 /pmc/articles/PMC6264393/ /pubmed/22113583 http://dx.doi.org/10.3390/molecules16119755 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
He, Jingwei
Söderling, Eva
Österblad, Monica
Vallittu, Pekka K.
Lassila, Lippo V. J.
Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title_full Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title_fullStr Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title_full_unstemmed Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title_short Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans
title_sort synthesis of methacrylate monomers with antibacterial effects against s. mutans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264393/
https://www.ncbi.nlm.nih.gov/pubmed/22113583
http://dx.doi.org/10.3390/molecules16119755
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AT vallittupekkak synthesisofmethacrylatemonomerswithantibacterialeffectsagainstsmutans
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