Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments...

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Detalles Bibliográficos
Autores principales: Lúcio, Ana Silvia Suassuna Carneiro, da Silva Almeida, Jackson Roberto Guedes, Barbosa-Filho, José Maria, Pita, João Carlos Lima Rodrigues, Branco, Marianna Vieira Sobral Castello, de Fátima Formiga Melo Diniz, Margareth, de Fátima Agra, Maria, da-Cunha, Emidio V.L., da Silva, Marcelo Sobral, Tavares, Josean Fechine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264400/
https://www.ncbi.nlm.nih.gov/pubmed/21860364
http://dx.doi.org/10.3390/molecules16087125
Descripción
Sumario:Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively.

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