Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments...

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Autores principales: Lúcio, Ana Silvia Suassuna Carneiro, da Silva Almeida, Jackson Roberto Guedes, Barbosa-Filho, José Maria, Pita, João Carlos Lima Rodrigues, Branco, Marianna Vieira Sobral Castello, de Fátima Formiga Melo Diniz, Margareth, de Fátima Agra, Maria, da-Cunha, Emidio V.L., da Silva, Marcelo Sobral, Tavares, Josean Fechine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264400/
https://www.ncbi.nlm.nih.gov/pubmed/21860364
http://dx.doi.org/10.3390/molecules16087125
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author Lúcio, Ana Silvia Suassuna Carneiro
da Silva Almeida, Jackson Roberto Guedes
Barbosa-Filho, José Maria
Pita, João Carlos Lima Rodrigues
Branco, Marianna Vieira Sobral Castello
de Fátima Formiga Melo Diniz, Margareth
de Fátima Agra, Maria
da-Cunha, Emidio V.L.
da Silva, Marcelo Sobral
Tavares, Josean Fechine
author_facet Lúcio, Ana Silvia Suassuna Carneiro
da Silva Almeida, Jackson Roberto Guedes
Barbosa-Filho, José Maria
Pita, João Carlos Lima Rodrigues
Branco, Marianna Vieira Sobral Castello
de Fátima Formiga Melo Diniz, Margareth
de Fátima Agra, Maria
da-Cunha, Emidio V.L.
da Silva, Marcelo Sobral
Tavares, Josean Fechine
author_sort Lúcio, Ana Silvia Suassuna Carneiro
collection PubMed
description Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively.
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spelling pubmed-62644002018-12-10 Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae) Lúcio, Ana Silvia Suassuna Carneiro da Silva Almeida, Jackson Roberto Guedes Barbosa-Filho, José Maria Pita, João Carlos Lima Rodrigues Branco, Marianna Vieira Sobral Castello de Fátima Formiga Melo Diniz, Margareth de Fátima Agra, Maria da-Cunha, Emidio V.L. da Silva, Marcelo Sobral Tavares, Josean Fechine Molecules Communication Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively. MDPI 2011-08-22 /pmc/articles/PMC6264400/ /pubmed/21860364 http://dx.doi.org/10.3390/molecules16087125 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Lúcio, Ana Silvia Suassuna Carneiro
da Silva Almeida, Jackson Roberto Guedes
Barbosa-Filho, José Maria
Pita, João Carlos Lima Rodrigues
Branco, Marianna Vieira Sobral Castello
de Fátima Formiga Melo Diniz, Margareth
de Fátima Agra, Maria
da-Cunha, Emidio V.L.
da Silva, Marcelo Sobral
Tavares, Josean Fechine
Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title_full Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title_fullStr Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title_full_unstemmed Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title_short Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
title_sort azaphenanthrene alkaloids with antitumoral activity from anaxagorea dolichocarpa sprague & sandwith (annonaceae)
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264400/
https://www.ncbi.nlm.nih.gov/pubmed/21860364
http://dx.doi.org/10.3390/molecules16087125
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