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Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment

The function and the role phytoceramide (PCER) and phytosphingosine (PSO) in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phyto...

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Autores principales: Jung, Jae-Chul, Lee, Yeonju, Moon, Sohyeon, Ryu, Jong Hoon, Oh, Seikwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264402/
https://www.ncbi.nlm.nih.gov/pubmed/22037667
http://dx.doi.org/10.3390/molecules16119090
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author Jung, Jae-Chul
Lee, Yeonju
Moon, Sohyeon
Ryu, Jong Hoon
Oh, Seikwan
author_facet Jung, Jae-Chul
Lee, Yeonju
Moon, Sohyeon
Ryu, Jong Hoon
Oh, Seikwan
author_sort Jung, Jae-Chul
collection PubMed
description The function and the role phytoceramide (PCER) and phytosphingosine (PSO) in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS) showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o.) recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.
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spelling pubmed-62644022018-12-10 Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment Jung, Jae-Chul Lee, Yeonju Moon, Sohyeon Ryu, Jong Hoon Oh, Seikwan Molecules Article The function and the role phytoceramide (PCER) and phytosphingosine (PSO) in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS) showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o.) recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease. MDPI 2011-10-28 /pmc/articles/PMC6264402/ /pubmed/22037667 http://dx.doi.org/10.3390/molecules16119090 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jung, Jae-Chul
Lee, Yeonju
Moon, Sohyeon
Ryu, Jong Hoon
Oh, Seikwan
Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title_full Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title_fullStr Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title_full_unstemmed Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title_short Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
title_sort phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264402/
https://www.ncbi.nlm.nih.gov/pubmed/22037667
http://dx.doi.org/10.3390/molecules16119090
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