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Modelling the impact of changes in the extracellular environment on the cytosolic free NAD(+)/NADH ratio during cell culture

Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in order to promote growth, proliferation and longevity. Glycolysis relies upon NAD(+) to accept electrons in the glyceraldehyde-3-phosphate dehydro...

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Detalles Bibliográficos
Autores principales:	Kelly, Ross A., Leedale, Joseph, Harrell, Andy, Beard, Daniel A., Randle, Laura E., Chadwick, Amy E., Webb, Steven D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264472/ https://www.ncbi.nlm.nih.gov/pubmed/30496306 http://dx.doi.org/10.1371/journal.pone.0207803

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