Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacter...

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Detalles Bibliográficos
Autores principales: Sun, Li, Wu, Jie, Luo, Min, Wang, Xiaoli, Pan, Man, Gou, Zhaopin, Sun, Dequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264486/
https://www.ncbi.nlm.nih.gov/pubmed/22113582
http://dx.doi.org/10.3390/molecules16119739
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author Sun, Li
Wu, Jie
Luo, Min
Wang, Xiaoli
Pan, Man
Gou, Zhaopin
Sun, Dequn
author_facet Sun, Li
Wu, Jie
Luo, Min
Wang, Xiaoli
Pan, Man
Gou, Zhaopin
Sun, Dequn
author_sort Sun, Li
collection PubMed
description A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.
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spelling pubmed-62644862018-12-10 Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities Sun, Li Wu, Jie Luo, Min Wang, Xiaoli Pan, Man Gou, Zhaopin Sun, Dequn Molecules Article A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed. MDPI 2011-11-23 /pmc/articles/PMC6264486/ /pubmed/22113582 http://dx.doi.org/10.3390/molecules16119739 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sun, Li
Wu, Jie
Luo, Min
Wang, Xiaoli
Pan, Man
Gou, Zhaopin
Sun, Dequn
Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_full Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_fullStr Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_full_unstemmed Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_short Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_sort diversity oriented design of various benzophenone derivatives and their in vitro antifungal and antibacterial activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264486/
https://www.ncbi.nlm.nih.gov/pubmed/22113582
http://dx.doi.org/10.3390/molecules16119739
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AT panman diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT gouzhaopin diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
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