NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives

5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-...

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Autores principales: Zhang, Xiaohui, Xu, Yao-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264492/
https://www.ncbi.nlm.nih.gov/pubmed/21725278
http://dx.doi.org/10.3390/molecules16075655
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author Zhang, Xiaohui
Xu, Yao-Zhong
author_facet Zhang, Xiaohui
Xu, Yao-Zhong
author_sort Zhang, Xiaohui
collection PubMed
description 5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.
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spelling pubmed-62644922018-12-10 NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives Zhang, Xiaohui Xu, Yao-Zhong Molecules Communication 5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents. MDPI 2011-07-01 /pmc/articles/PMC6264492/ /pubmed/21725278 http://dx.doi.org/10.3390/molecules16075655 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Zhang, Xiaohui
Xu, Yao-Zhong
NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title_full NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title_fullStr NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title_full_unstemmed NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title_short NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
title_sort nmr and uv studies of 4-thio-2′-deoxyuridine and its derivatives
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264492/
https://www.ncbi.nlm.nih.gov/pubmed/21725278
http://dx.doi.org/10.3390/molecules16075655
work_keys_str_mv AT zhangxiaohui nmranduvstudiesof4thio2deoxyuridineanditsderivatives
AT xuyaozhong nmranduvstudiesof4thio2deoxyuridineanditsderivatives

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