A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins....

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Detalles Bibliográficos
Autores principales: Hwang, In-Taek, Lee, Sun-Ah, Hwang, Jin-Soo, Lee, Kee-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264530/
https://www.ncbi.nlm.nih.gov/pubmed/21792149
http://dx.doi.org/10.3390/molecules16086313
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author Hwang, In-Taek
Lee, Sun-Ah
Hwang, Jin-Soo
Lee, Kee-In
author_facet Hwang, In-Taek
Lee, Sun-Ah
Hwang, Jin-Soo
Lee, Kee-In
author_sort Hwang, In-Taek
collection PubMed
description An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
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spelling pubmed-62645302018-12-10 A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU Hwang, In-Taek Lee, Sun-Ah Hwang, Jin-Soo Lee, Kee-In Molecules Communication An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity. MDPI 2011-07-26 /pmc/articles/PMC6264530/ /pubmed/21792149 http://dx.doi.org/10.3390/molecules16086313 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Hwang, In-Taek
Lee, Sun-Ah
Hwang, Jin-Soo
Lee, Kee-In
A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_full A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_fullStr A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_full_unstemmed A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_short A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_sort facile synthesis of highly functionalized 4-arylcoumarins via kostanecki reactions mediated by dbu
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264530/
https://www.ncbi.nlm.nih.gov/pubmed/21792149
http://dx.doi.org/10.3390/molecules16086313
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