Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of (1)H-NMR, (13)C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new deriva...

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Detalles Bibliográficos
Autores principales: Zheng, Fei Lang, Ban, Shu Rong, Feng, Xiu E, Zhao, Cheng Xiao, Lin, Wenhan, Li, Qing Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264553/
https://www.ncbi.nlm.nih.gov/pubmed/21677603
http://dx.doi.org/10.3390/molecules16064897
Descripción
Sumario:A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of (1)H-NMR, (13)C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

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