Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of (1)H-NMR, (13)C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new deriva...

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Detalles Bibliográficos
Autores principales: Zheng, Fei Lang, Ban, Shu Rong, Feng, Xiu E, Zhao, Cheng Xiao, Lin, Wenhan, Li, Qing Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264553/
https://www.ncbi.nlm.nih.gov/pubmed/21677603
http://dx.doi.org/10.3390/molecules16064897
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author Zheng, Fei Lang
Ban, Shu Rong
Feng, Xiu E
Zhao, Cheng Xiao
Lin, Wenhan
Li, Qing Shan
author_facet Zheng, Fei Lang
Ban, Shu Rong
Feng, Xiu E
Zhao, Cheng Xiao
Lin, Wenhan
Li, Qing Shan
author_sort Zheng, Fei Lang
collection PubMed
description A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of (1)H-NMR, (13)C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.
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spelling pubmed-62645532018-12-10 Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives Zheng, Fei Lang Ban, Shu Rong Feng, Xiu E Zhao, Cheng Xiao Lin, Wenhan Li, Qing Shan Molecules Article A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of (1)H-NMR, (13)C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed. MDPI 2011-06-14 /pmc/articles/PMC6264553/ /pubmed/21677603 http://dx.doi.org/10.3390/molecules16064897 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zheng, Fei Lang
Ban, Shu Rong
Feng, Xiu E
Zhao, Cheng Xiao
Lin, Wenhan
Li, Qing Shan
Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title_full Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title_fullStr Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title_full_unstemmed Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title_short Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
title_sort synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264553/
https://www.ncbi.nlm.nih.gov/pubmed/21677603
http://dx.doi.org/10.3390/molecules16064897
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