Cargando…
Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264564/ https://www.ncbi.nlm.nih.gov/pubmed/22116046 http://dx.doi.org/10.3390/molecules16119764 |
_version_ | 1783375526488965120 |
---|---|
author | Yin, Peipei Zhao, Shan Chen, Siyu Liu, Jieyuan Shi, Lingling Wang, Xinjie Liu, Yujun Ma, Chao |
author_facet | Yin, Peipei Zhao, Shan Chen, Siyu Liu, Jieyuan Shi, Lingling Wang, Xinjie Liu, Yujun Ma, Chao |
author_sort | Yin, Peipei |
collection | PubMed |
description | Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues. |
format | Online Article Text |
id | pubmed-6264564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62645642018-12-10 Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume Yin, Peipei Zhao, Shan Chen, Siyu Liu, Jieyuan Shi, Lingling Wang, Xinjie Liu, Yujun Ma, Chao Molecules Article Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues. MDPI 2011-11-24 /pmc/articles/PMC6264564/ /pubmed/22116046 http://dx.doi.org/10.3390/molecules16119764 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Yin, Peipei Zhao, Shan Chen, Siyu Liu, Jieyuan Shi, Lingling Wang, Xinjie Liu, Yujun Ma, Chao Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title | Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title_full | Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title_fullStr | Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title_full_unstemmed | Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title_short | Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume |
title_sort | hypoglycemic and hypolipidemic effects of polyphenols from burs of castanea mollissima blume |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264564/ https://www.ncbi.nlm.nih.gov/pubmed/22116046 http://dx.doi.org/10.3390/molecules16119764 |
work_keys_str_mv | AT yinpeipei hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT zhaoshan hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT chensiyu hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT liujieyuan hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT shilingling hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT wangxinjie hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT liuyujun hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume AT machao hypoglycemicandhypolipidemiceffectsofpolyphenolsfrombursofcastaneamollissimablume |