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Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume

Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied...

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Autores principales: Yin, Peipei, Zhao, Shan, Chen, Siyu, Liu, Jieyuan, Shi, Lingling, Wang, Xinjie, Liu, Yujun, Ma, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264564/
https://www.ncbi.nlm.nih.gov/pubmed/22116046
http://dx.doi.org/10.3390/molecules16119764
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author Yin, Peipei
Zhao, Shan
Chen, Siyu
Liu, Jieyuan
Shi, Lingling
Wang, Xinjie
Liu, Yujun
Ma, Chao
author_facet Yin, Peipei
Zhao, Shan
Chen, Siyu
Liu, Jieyuan
Shi, Lingling
Wang, Xinjie
Liu, Yujun
Ma, Chao
author_sort Yin, Peipei
collection PubMed
description Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues.
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spelling pubmed-62645642018-12-10 Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume Yin, Peipei Zhao, Shan Chen, Siyu Liu, Jieyuan Shi, Lingling Wang, Xinjie Liu, Yujun Ma, Chao Molecules Article Substantial evidence suggests that phenolic extracts of Castanea mollissima spiny burs (CMPE) increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats CMPE were orally administrated at doses of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were measured spectrophotometrically. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, oral administration of CMPE at a dose of 300 mg/kg caused significant decreases in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, the 300 mg/kg dosage caused a significant body weight loss in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as a drug to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues. MDPI 2011-11-24 /pmc/articles/PMC6264564/ /pubmed/22116046 http://dx.doi.org/10.3390/molecules16119764 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yin, Peipei
Zhao, Shan
Chen, Siyu
Liu, Jieyuan
Shi, Lingling
Wang, Xinjie
Liu, Yujun
Ma, Chao
Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title_full Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title_fullStr Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title_full_unstemmed Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title_short Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
title_sort hypoglycemic and hypolipidemic effects of polyphenols from burs of castanea mollissima blume
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264564/
https://www.ncbi.nlm.nih.gov/pubmed/22116046
http://dx.doi.org/10.3390/molecules16119764
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