Cargando…

Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd(2)(dba)(3)/DPPF/Cs(2)CO(3)/toluene combination...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Gang, Zhang, Hao, Wang, Xiaojian, Li, Chun, Huang, Haihong, Yin, Dali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264567/ https://www.ncbi.nlm.nih.gov/pubmed/21847070 http://dx.doi.org/10.3390/molecules16086985

Ejemplares similares

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents
por: Zhang, Dongfeng, et al.
Publicado: (2014)

Systematic Evaluation of Structure-Activity Relationships of the Riminophenazine Class and Discovery of a C2 Pyridylamino Series for the Treatment of Multidrug-Resistant Tuberculosis
por: Liu, Binna, et al.
Publicado: (2012)

Riminophenazine Derivatives as Potential Antituberculosis Agents: Synthesis, Biological, and Electrochemical Evaluations
por: Bvumbi, Mpelegeng Victoria, et al.
Publicado: (2021)

Substituted Amides of Pyrazine-2-carboxylic acids: Synthesis and Biological Activity.
por: Dolezal, Martin, et al.
Publicado: (2002)

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies
por: Bouz, Ghada, et al.
Publicado: (2019)

Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents
por: Bvumbi, Mpelegeng Victoria
Publicado: (2020)

Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents
por: Xu, Jia, et al.
Publicado: (2020)

Carbazole- and Triphenylamine-Substituted Pyrimidines: Synthesis and Photophysical Properties
por: Achelle, Sylvain, et al.
Publicado: (2019)

(Z,Z)-N′′-[Amino(pyrazin-2-yl)methylene]pyrazine-2-carbohydrazonamide
por: Zhang, Ya-Wen, et al.
Publicado: (2009)

Chemo‐Enzymatic Synthesis of Pyrazines and Pyrroles
por: Xu, Jin, et al.
Publicado: (2018)

N-(Pyrazin-2-yl)aniline
por: Wan Saffiee, Wan Ainna Mardhiah, et al.
Publicado: (2008)

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides
por: Semelkova, Lucia, et al.
Publicado: (2015)

Effects of Pyrazine Derivatives and Substituted Positions on the Photoelectric Properties and Electromemory Performance of D–A–D Series Compounds
por: Song, Xuejing, et al.
Publicado: (2018)

Cytidine deaminases catalyze the conversion of N(S,O)(4)-substituted pyrimidine nucleosides
por: Urbelienė, Nina, et al.
Publicado: (2023)

Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
por: Wang, Han, et al.
Publicado: (2012)

Design, Synthesis, and In Vitro Activity of Pyrazine Compounds
por: Parsonidis, Panagiotis, et al.
Publicado: (2019)

Crystal structure of a tetrakis-substituted pyrazine compound: 2,3,5,6-tetrakis(bromomethyl)pyrazine
por: Assoumatine, Tokouré, et al.
Publicado: (2014)

Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones—In Vitro and In Silico Study
por: Stepanić, Višnja, et al.
Publicado: (2019)

N-(Pyrazin-2-yl)-4-toluidine
por: Wan Saffiee, Wan Ainna Mardhiah, et al.
Publicado: (2008)

The crystal structures and Hirshfeld surface analyses of a cadmium(II) and a zinc(II) mononuclear complex of the new tetrakis-substituted pyrazine ligand N,N′,N′′,N′′′-[pyrazine-2,3,5,6-tetrayltetrakis(methylene)]tetrakis(N-methylaniline)
por: Tesouro Vallina, Ana, et al.
Publicado: (2020)

Synthesis of New Pyrazole and Pyrimidine Steroidal Derivatives
por: Rivera, Daniel G., et al.
Publicado: (2003)

Crystal structures and Hirshfeld surface analyses of two new tetrakis-substituted pyrazines and a degredation product
por: Tesouro Vallina, Ana, et al.
Publicado: (2020)

Synthesis and characterization of novel iminobenzoates with terminal pyrazine moieties
por: Ahmad, Mushtaq, et al.
Publicado: (2018)

Synthesis, Herbicidal Activity, Crop Safety and Soil Degradation of Pyrimidine- and Triazine-Substituted Chlorsulfuron Derivatives
por: Wu, Lei, et al.
Publicado: (2022)

A Sulfonic Acid Polyvinyl Pyridinium Ionic Liquid Catalyzes the Multi-Component Synthesis of Spiro-indoline-3,5′-pyrano[2,3-d]-pyrimidines and -Pyrazines
por: Khalaj, Mehdi, et al.
Publicado: (2023)

4-Chloro-N-(pyrazin-2-yl)aniline
por: Wan Saffiee, Wan Ainna Mardhiah, et al.
Publicado: (2008)

New pyrimidine-N-β-D-glucosides: synthesis, biological evaluation, and molecular docking investigations
por: KAHRİMAN, Nuran, et al.
Publicado: (2023)

Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative
por: Fang, Zhiyuan, et al.
Publicado: (2019)

Bis(5-methylpyrazine-2-carboxylato-κ(2) N,O)nickel(II)
por: Shi, Qi-Ying, et al.
Publicado: (2012)

Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities
por: Abdel Moty, Samia G., et al.
Publicado: (2016)

Investigation of rotameric conformations of substituted imidazo-[1,2-a]pyrazine: experimental and theoretical approaches
por: Kumar, Gulshan, et al.
Publicado: (2018)

Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery
por: Huigens, Robert W., et al.
Publicado: (2022)

Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate
por: Ermolat'ev, Denis S., et al.
Publicado: (2003)

Synthesis of New Perhydropyrrolo[1,2-a]pyrazine Derivatives and Their Evaluation in Animal Models of Epilepsy
por: Dawidowski, Maciej, et al.
Publicado: (2014)

Dibromidobis(pyrazine-2-carboxamide-κN (4))zinc
por: Shirvan, Sadif A., et al.
Publicado: (2012)

N-(2-Chloroethyl)pyrazine-2-carboxamide
por: da Silva Lima, Camilo H., et al.
Publicado: (2010)

Microwave-Assisted Synthesis of New N(1),N(4)-Substituted Thiosemicarbazones
por: dos Reis, Camilla Moretto, et al.
Publicado: (2011)

TBHP-mediated oxidative synthesis of substituted pyrimido[4,5-d]pyrimidines from N-uracil amidines and methylarenes under metal free conditions
por: Debnath, Pradip
Publicado: (2019)

Crystal structures of N-(pyridin-2-ylmethyl)pyrazine-2-carboxamide (monoclinic polymorph) and N-(pyridin-4-ylmethyl)pyrazine-2-carboxamide
por: Cati, Dilovan S., et al.
Publicado: (2014)

N (2′),N (5′)-Diisopropylidenepyrazine-2,5-dicarbohydrazide dihydrate
por: Ding, Miao, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_071bbjd3q2pidc410g7bg79ggp