Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin

In this study a complex of naringenin with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), di...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Jiping, Liu, Benguo, Yuan, Erdong, Ma, Yuxiang, Zhu, Yongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264575/
https://www.ncbi.nlm.nih.gov/pubmed/20657449
http://dx.doi.org/10.3390/molecules15064401
_version_ 1783375529023373312
author Wen, Jiping
Liu, Benguo
Yuan, Erdong
Ma, Yuxiang
Zhu, Yongyi
author_facet Wen, Jiping
Liu, Benguo
Yuan, Erdong
Ma, Yuxiang
Zhu, Yongyi
author_sort Wen, Jiping
collection PubMed
description In this study a complex of naringenin with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-β-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 μg/mL to 1,272.31 μg/mL.
format Online
Article
Text
id pubmed-6264575
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62645752018-12-04 Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin Wen, Jiping Liu, Benguo Yuan, Erdong Ma, Yuxiang Zhu, Yongyi Molecules Communication In this study a complex of naringenin with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-β-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 μg/mL to 1,272.31 μg/mL. MDPI 2010-06-18 /pmc/articles/PMC6264575/ /pubmed/20657449 http://dx.doi.org/10.3390/molecules15064401 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Wen, Jiping
Liu, Benguo
Yuan, Erdong
Ma, Yuxiang
Zhu, Yongyi
Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title_full Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title_fullStr Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title_full_unstemmed Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title_short Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
title_sort preparation and physicochemical properties of the complex of naringenin with hydroxypropyl-β-cyclodextrin
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264575/
https://www.ncbi.nlm.nih.gov/pubmed/20657449
http://dx.doi.org/10.3390/molecules15064401
work_keys_str_mv AT wenjiping preparationandphysicochemicalpropertiesofthecomplexofnaringeninwithhydroxypropylbcyclodextrin
AT liubenguo preparationandphysicochemicalpropertiesofthecomplexofnaringeninwithhydroxypropylbcyclodextrin
AT yuanerdong preparationandphysicochemicalpropertiesofthecomplexofnaringeninwithhydroxypropylbcyclodextrin
AT mayuxiang preparationandphysicochemicalpropertiesofthecomplexofnaringeninwithhydroxypropylbcyclodextrin
AT zhuyongyi preparationandphysicochemicalpropertiesofthecomplexofnaringeninwithhydroxypropylbcyclodextrin

Ejemplares similares