Locked and Unlocked Nucleosides in Functional Nucleic Acids

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review...

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Detalles Bibliográficos
Autores principales: Doessing, Holger, Vester, Birte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264650/
https://www.ncbi.nlm.nih.gov/pubmed/21629180
http://dx.doi.org/10.3390/molecules16064511
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author Doessing, Holger
Vester, Birte
author_facet Doessing, Holger
Vester, Birte
author_sort Doessing, Holger
collection PubMed
description Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
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spelling pubmed-62646502018-12-10 Locked and Unlocked Nucleosides in Functional Nucleic Acids Doessing, Holger Vester, Birte Molecules Review Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes. MDPI 2011-05-27 /pmc/articles/PMC6264650/ /pubmed/21629180 http://dx.doi.org/10.3390/molecules16064511 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Doessing, Holger
Vester, Birte
Locked and Unlocked Nucleosides in Functional Nucleic Acids
title Locked and Unlocked Nucleosides in Functional Nucleic Acids
title_full Locked and Unlocked Nucleosides in Functional Nucleic Acids
title_fullStr Locked and Unlocked Nucleosides in Functional Nucleic Acids
title_full_unstemmed Locked and Unlocked Nucleosides in Functional Nucleic Acids
title_short Locked and Unlocked Nucleosides in Functional Nucleic Acids
title_sort locked and unlocked nucleosides in functional nucleic acids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264650/
https://www.ncbi.nlm.nih.gov/pubmed/21629180
http://dx.doi.org/10.3390/molecules16064511
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AT vesterbirte lockedandunlockednucleosidesinfunctionalnucleicacids

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