An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides

A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allow...

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Detalles Bibliográficos
Autores principales: Sengmany, Stéphane, Gall, Erwan Le, Léonel, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264652/
https://www.ncbi.nlm.nih.gov/pubmed/21716176
http://dx.doi.org/10.3390/molecules16075550
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author Sengmany, Stéphane
Gall, Erwan Le
Léonel, Eric
author_facet Sengmany, Stéphane
Gall, Erwan Le
Léonel, Eric
author_sort Sengmany, Stéphane
collection PubMed
description A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields.
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spelling pubmed-62646522018-12-10 An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides Sengmany, Stéphane Gall, Erwan Le Léonel, Eric Molecules Communication A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields. MDPI 2011-06-29 /pmc/articles/PMC6264652/ /pubmed/21716176 http://dx.doi.org/10.3390/molecules16075550 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Sengmany, Stéphane
Gall, Erwan Le
Léonel, Eric
An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title_full An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title_fullStr An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title_full_unstemmed An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title_short An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
title_sort electrochemical synthesis of functionalized arylpyrimidines from 4-amino-6-chloropyrimidines and aryl halides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264652/
https://www.ncbi.nlm.nih.gov/pubmed/21716176
http://dx.doi.org/10.3390/molecules16075550
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