Synthesis and SAR Study of Novel Peptide Aldehydes as Inhibitors of 20S Proteasome

Based on the analysis of the crystal structure of MG101 (1) and 20S proteasomes, a new series of peptide aldehyde derivatives were designed and synthesized. Their ability to inhibit 20S proteasome was assayed. Among them, Cbz-Glu(OtBu)-Phe-Leucinal (3c), Cbz-Glu(OtBu)-Leu-Leucinal (3d), and Boc-Ser(...

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Detalles Bibliográficos
Autores principales: Ma, Yuheng, Xu, Bo, Fang, Yuan, Yang, Zhenjun, Cui, Jingrong, Zhang, Liangren, Zhang, Lihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264673/
https://www.ncbi.nlm.nih.gov/pubmed/21894088
http://dx.doi.org/10.3390/molecules16097551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264673/
https://www.ncbi.nlm.nih.gov/pubmed/21894088
http://dx.doi.org/10.3390/molecules16097551

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