Synthesis and Adrenolytic Activity of New Propanolamines

The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxy­methyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic...

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Autores principales: Groszek, Grażyna, Bajek, Agata, Bis, Agnieszka, Nowak-Król, Agnieszka, Bednarski, Marek, Siwek, Agata, Filipek, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264682/
https://www.ncbi.nlm.nih.gov/pubmed/20657415
http://dx.doi.org/10.3390/molecules15063887
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author Groszek, Grażyna
Bajek, Agata
Bis, Agnieszka
Nowak-Król, Agnieszka
Bednarski, Marek
Siwek, Agata
Filipek, Barbara
author_facet Groszek, Grażyna
Bajek, Agata
Bis, Agnieszka
Nowak-Król, Agnieszka
Bednarski, Marek
Siwek, Agata
Filipek, Barbara
author_sort Groszek, Grażyna
collection PubMed
description The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxy­methyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for α(1)-, α(2)- and β(1)-adrenoceptor binding affinity.
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spelling pubmed-62646822018-12-04 Synthesis and Adrenolytic Activity of New Propanolamines Groszek, Grażyna Bajek, Agata Bis, Agnieszka Nowak-Król, Agnieszka Bednarski, Marek Siwek, Agata Filipek, Barbara Molecules Article The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxy­methyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for α(1)-, α(2)- and β(1)-adrenoceptor binding affinity. MDPI 2010-05-28 /pmc/articles/PMC6264682/ /pubmed/20657415 http://dx.doi.org/10.3390/molecules15063887 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Groszek, Grażyna
Bajek, Agata
Bis, Agnieszka
Nowak-Król, Agnieszka
Bednarski, Marek
Siwek, Agata
Filipek, Barbara
Synthesis and Adrenolytic Activity of New Propanolamines
title Synthesis and Adrenolytic Activity of New Propanolamines
title_full Synthesis and Adrenolytic Activity of New Propanolamines
title_fullStr Synthesis and Adrenolytic Activity of New Propanolamines
title_full_unstemmed Synthesis and Adrenolytic Activity of New Propanolamines
title_short Synthesis and Adrenolytic Activity of New Propanolamines
title_sort synthesis and adrenolytic activity of new propanolamines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264682/
https://www.ncbi.nlm.nih.gov/pubmed/20657415
http://dx.doi.org/10.3390/molecules15063887
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AT bisagnieszka synthesisandadrenolyticactivityofnewpropanolamines
AT nowakkrolagnieszka synthesisandadrenolyticactivityofnewpropanolamines
AT bednarskimarek synthesisandadrenolyticactivityofnewpropanolamines
AT siwekagata synthesisandadrenolyticactivityofnewpropanolamines
AT filipekbarbara synthesisandadrenolyticactivityofnewpropanolamines

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