Enantioselective Addition of Allyltin Reagents to Amino Aldehydes Catalyzed with Bis(oxazolinyl)phenylrhodium(III) Aqua Complexes

Bis(oxazolinyl)phenylrhodium(III) aqua complexes, (Phebox)RhX(2)(H(2)O) [X = Cl, Br], were found to be efficient Lewis acid catalysts for the enantioselective addition of allyl- and methallyltributyltin reagents to amino aldehydes. The reactions proceed smoothly in the presence of 5–10 mol % of (Phe...

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Detalles Bibliográficos
Autores principales: Motoyama, Yukihiro, Sakakura, Takatoshi, Takemoto, Toshihide, Shimozono, Kayoko, Aoki, Katsuyuki, Nishiyama, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264686/
https://www.ncbi.nlm.nih.gov/pubmed/21709621
http://dx.doi.org/10.3390/molecules16075387
Descripción
Sumario:Bis(oxazolinyl)phenylrhodium(III) aqua complexes, (Phebox)RhX(2)(H(2)O) [X = Cl, Br], were found to be efficient Lewis acid catalysts for the enantioselective addition of allyl- and methallyltributyltin reagents to amino aldehydes. The reactions proceed smoothly in the presence of 5–10 mol % of (Phebox)RhX(2)(H(2)O) complex at ambient temperature to give the corresponding amino alcohols with modest to good enantioselectivity (up to 94% ee).

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