The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.

In this paper, ultrasound-assisted extraction (UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L. The five anthraquinones were quantified and analyzed by high performance liquid chromatography coupled with UV detection...

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Autores principales: Zhao, Li-Chun, Liang, Jian, Li, Wei, Cheng, Kun-Mu, Xia, Xianghua, Deng, Xin, Yang, Geng-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264690/
https://www.ncbi.nlm.nih.gov/pubmed/21765390
http://dx.doi.org/10.3390/molecules16075928
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author Zhao, Li-Chun
Liang, Jian
Li, Wei
Cheng, Kun-Mu
Xia, Xianghua
Deng, Xin
Yang, Geng-Liang
author_facet Zhao, Li-Chun
Liang, Jian
Li, Wei
Cheng, Kun-Mu
Xia, Xianghua
Deng, Xin
Yang, Geng-Liang
author_sort Zhao, Li-Chun
collection PubMed
description In this paper, ultrasound-assisted extraction (UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L. The five anthraquinones were quantified and analyzed by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time parameters, the three main factors for UAE, were optimized with response surface methodology (RSM) to obtain the highest extraction efficiency. The optimal conditions were the use of 84% methanol as solvent, an extraction time of 33 min and an extraction temperature of 67 °C. Under these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance indicated a high goodness of model fit and the success of RSM method for optimizing anthraquinones extraction in Rheum palmatum L.
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spelling pubmed-62646902018-12-10 The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L. Zhao, Li-Chun Liang, Jian Li, Wei Cheng, Kun-Mu Xia, Xianghua Deng, Xin Yang, Geng-Liang Molecules Article In this paper, ultrasound-assisted extraction (UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L. The five anthraquinones were quantified and analyzed by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time parameters, the three main factors for UAE, were optimized with response surface methodology (RSM) to obtain the highest extraction efficiency. The optimal conditions were the use of 84% methanol as solvent, an extraction time of 33 min and an extraction temperature of 67 °C. Under these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance indicated a high goodness of model fit and the success of RSM method for optimizing anthraquinones extraction in Rheum palmatum L. MDPI 2011-07-15 /pmc/articles/PMC6264690/ /pubmed/21765390 http://dx.doi.org/10.3390/molecules16075928 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhao, Li-Chun
Liang, Jian
Li, Wei
Cheng, Kun-Mu
Xia, Xianghua
Deng, Xin
Yang, Geng-Liang
The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title_full The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title_fullStr The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title_full_unstemmed The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title_short The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L.
title_sort use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from rheum palmatum l.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264690/
https://www.ncbi.nlm.nih.gov/pubmed/21765390
http://dx.doi.org/10.3390/molecules16075928
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