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Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compound...

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Autores principales: Liu, Dong-Ping, Luo, Qiang, Wang, Guang-Hui, Xu, Yang, Zhang, Xiao-Kun, Chen, Quan-Cheng, Chen, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264713/
https://www.ncbi.nlm.nih.gov/pubmed/21792151
http://dx.doi.org/10.3390/molecules16086339
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author Liu, Dong-Ping
Luo, Qiang
Wang, Guang-Hui
Xu, Yang
Zhang, Xiao-Kun
Chen, Quan-Cheng
Chen, Hai-Feng
author_facet Liu, Dong-Ping
Luo, Qiang
Wang, Guang-Hui
Xu, Yang
Zhang, Xiao-Kun
Chen, Quan-Cheng
Chen, Hai-Feng
author_sort Liu, Dong-Ping
collection PubMed
description A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 7–9, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.
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spelling pubmed-62647132018-12-10 Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation Liu, Dong-Ping Luo, Qiang Wang, Guang-Hui Xu, Yang Zhang, Xiao-Kun Chen, Quan-Cheng Chen, Hai-Feng Molecules Article A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 7–9, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα. MDPI 2011-07-26 /pmc/articles/PMC6264713/ /pubmed/21792151 http://dx.doi.org/10.3390/molecules16086339 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Dong-Ping
Luo, Qiang
Wang, Guang-Hui
Xu, Yang
Zhang, Xiao-Kun
Chen, Quan-Cheng
Chen, Hai-Feng
Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title_full Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title_fullStr Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title_full_unstemmed Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title_short Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation
title_sort furocoumarin derivatives from radix angelicae dahuricae and their effects on rxrα transcriptional regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264713/
https://www.ncbi.nlm.nih.gov/pubmed/21792151
http://dx.doi.org/10.3390/molecules16086339
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