Cargando…

Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies

A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a–g were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pretreated with 1 μM phenylephrine (PE). Several compounds showed potent vasorelaxant activities. Compound 10...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Xiaowu, Wang, Yanming, Liu, Tao, Wu, Peng, Gao, Jiadi, Xu, Jianchao, Yang, Bo, Hu, Yongzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264760/ https://www.ncbi.nlm.nih.gov/pubmed/21959298 http://dx.doi.org/10.3390/molecules16108257

Ejemplares similares

Synthesis, Biological Activities, and Quantitative Structure–Activity Relationship (QSAR) Study of Novel Camptothecin Analogues
por: Wu, Dan, et al.
Publicado: (2015)

Structural relationships and vasorelaxant activity of monoterpenes
por: Cardoso Lima, Tamires, et al.
Publicado: (2012)

Quantitative structure–activity relationship (QSAR) and molecular docking of xanthone derivatives as anti-tuberculosis agents
por: Yuanita, Emmy, et al.
Publicado: (2020)

The Psychonauts’ Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity
por: Catalani, Valeria, et al.
Publicado: (2021)

Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives
por: Matos, Maria João, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as CCR5 Antagonists
por: Liu, Tao, et al.
Publicado: (2013)

Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2015)

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents
por: Dawood, Dina H., et al.
Publicado: (2021)

Creation of Novel Antihypertensive Agent via Structure-Activity Relationship Study on Phytochemicals towards Vasorelaxant Activity
por: Loh, Yean Chun, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents
por: Wang, Hui, et al.
Publicado: (2018)

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
por: Sabt, Ahmed, et al.
Publicado: (2018)

Quantitative Structure‐activity Relationship (QSAR) Models for Docking Score Correction
por: Fukunishi, Yoshifumi, et al.
Publicado: (2016)

Structure activity relationship (SAR) and quantitative structure activity relationship (QSAR) studies showed plant flavonoids as potential inhibitors of dengue NS2B-NS3 protease
por: Sarwar, Muhammad Waseem, et al.
Publicado: (2018)

Sildenafil does not enhance but rather attenuates vasorelaxant effects of antidiabetic agents
por: Peuler, Jacob D., et al.
Publicado: (2015)

Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project
por: Honma, Masamitsu, et al.
Publicado: (2019)

Quantitative Structure-Activity Relationship (QSAR) Studies on the Toxic Effects of Nitroaromatic Compounds (NACs): A Systematic Review
por: Huang, Tao, et al.
Publicado: (2021)

Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction
por: Frimayanti, Neni, et al.
Publicado: (2011)

Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure–Activity Relationship) Models
por: Bouarab-Chibane, Lynda, et al.
Publicado: (2019)

Synthesis and Biological Activity of Novel Oxazinyl Flavonoids as Antiviral and Anti-Phytopathogenic Fungus Agents
por: Ma, Yucong, et al.
Publicado: (2022)

3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors
por: Fang, Yajing, et al.
Publicado: (2016)

Microwave Assisted Synthesis, Characterization and Biological Activities of Ferrocenyl Chalcones and Their QSAR Analysis
por: Yadav, Dinesh K., et al.
Publicado: (2019)

Synthesis, Biological Evaluation, and QSAR Studies of 3-Iodochromone Derivatives as Potential Fungicides
por: Kaushik, Parshant, et al.
Publicado: (2021)

QSAR Analysis of Benzophenone Derivatives as Antimalarial Agents
por: Mahajan, Supriya, et al.
Publicado: (2012)

Construction of a QSAR Model Based on Flavonoids and Screening of Natural Pancreatic Lipase Inhibitors
por: Yuan, Yutong, et al.
Publicado: (2023)

Elucidating the Structure-Activity Relationships of the Vasorelaxation and Antioxidation Properties of Thionicotinic Acid Derivatives
por: Prachayasittikul, Supaluk, et al.
Publicado: (2010)

Screening, Synthesis, and QSAR Research on Cinnamaldehyde-Amino Acid Schiff Base Compounds as Antibacterial Agents
por: Wang, Hui, et al.
Publicado: (2018)

Quantitative structure-activity relationships (QSARs) for estrogen binding to the estrogen receptor: predictions across species.
por: Tong, W, et al.
Publicado: (1997)

QSAR DataBank repository: open and linked qualitative and quantitative structure–activity relationship models
por: Ruusmann, V, et al.
Publicado: (2015)

Quantitative Structure–Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure
por: Cai, Zhengguo, et al.
Publicado: (2022)

Vasorelaxant effect of Prunus yedoensis bark
por: Lee, Kyungjin, et al.
Publicado: (2013)

Hydrogen Sulfide and Endothelium-Dependent Vasorelaxation
por: Bełtowski, Jerzy, et al.
Publicado: (2014)

Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents
por: Yao, Yangyang, et al.
Publicado: (2017)

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents
por: Santos-Garcia, Letícia, et al.
Publicado: (2018)

Construction of an MLR-QSAR Model Based on Dietary Flavonoids and Screening of Natural α-Glucosidase Inhibitors
por: Yang, Ting, et al.
Publicado: (2022)

Synthesis of acetamidosulfonamide derivatives with antioxidative and QSAR studies
por: Worachartcheewan, Apilak, et al.
Publicado: (2022)

Guidance for good practice in the application of machine learning in development of toxicological quantitative structure-activity relationships (QSARs)
por: Belfield, Samuel J., et al.
Publicado: (2023)

Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides
por: Beč, Anja, et al.
Publicado: (2022)

Synthesis, biological and computational studies of flavonoid acetamide derivatives
por: Isika, Daniel K., et al.
Publicado: (2022)

Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents
por: Hu, Yunzhen, et al.
Publicado: (2012)

The Potential Role of Everlasting Flower (Helichrysum stoechas Moench) as an Antihypertensive Agent: Vasorelaxant Effects in the Rat Aorta
por: Valero, Marta Sofía, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2kml2p5lcb6jojrob1vk1fe2n1