Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives

The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shif...

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Autores principales: Petrova, Marina, Muhamadejev, Ruslan, Vigante, Brigita, Cekavicus, Brigita, Plotniece, Aiva, Duburs, Gunars, Liepinsh, Edvards
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264772/
https://www.ncbi.nlm.nih.gov/pubmed/21931285
http://dx.doi.org/10.3390/molecules16098041
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author Petrova, Marina
Muhamadejev, Ruslan
Vigante, Brigita
Cekavicus, Brigita
Plotniece, Aiva
Duburs, Gunars
Liepinsh, Edvards
author_facet Petrova, Marina
Muhamadejev, Ruslan
Vigante, Brigita
Cekavicus, Brigita
Plotniece, Aiva
Duburs, Gunars
Liepinsh, Edvards
author_sort Petrova, Marina
collection PubMed
description The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shift differences in the (1)H-NMR spectra.
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spelling pubmed-62647722018-12-10 Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives Petrova, Marina Muhamadejev, Ruslan Vigante, Brigita Cekavicus, Brigita Plotniece, Aiva Duburs, Gunars Liepinsh, Edvards Molecules Communication The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shift differences in the (1)H-NMR spectra. MDPI 2011-09-19 /pmc/articles/PMC6264772/ /pubmed/21931285 http://dx.doi.org/10.3390/molecules16098041 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Petrova, Marina
Muhamadejev, Ruslan
Vigante, Brigita
Cekavicus, Brigita
Plotniece, Aiva
Duburs, Gunars
Liepinsh, Edvards
Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title_full Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title_fullStr Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title_full_unstemmed Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title_short Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
title_sort intramolecular c-h···o hydrogen bonding in 1,4-dihydropyridine derivatives
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264772/
https://www.ncbi.nlm.nih.gov/pubmed/21931285
http://dx.doi.org/10.3390/molecules16098041
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