Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for...

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Autores principales: Lim, Eunyoung, Ricci, Jeremy, Jung, Mankil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264775/
https://www.ncbi.nlm.nih.gov/pubmed/22124203
http://dx.doi.org/10.3390/molecules16129886
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author Lim, Eunyoung
Ricci, Jeremy
Jung, Mankil
author_facet Lim, Eunyoung
Ricci, Jeremy
Jung, Mankil
author_sort Lim, Eunyoung
collection PubMed
description Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.
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spelling pubmed-62647752018-12-10 Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties Lim, Eunyoung Ricci, Jeremy Jung, Mankil Molecules Article Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization. MDPI 2011-11-28 /pmc/articles/PMC6264775/ /pubmed/22124203 http://dx.doi.org/10.3390/molecules16129886 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lim, Eunyoung
Ricci, Jeremy
Jung, Mankil
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_full Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_fullStr Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_full_unstemmed Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_short Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_sort synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264775/
https://www.ncbi.nlm.nih.gov/pubmed/22124203
http://dx.doi.org/10.3390/molecules16129886
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AT jungmankil synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties

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