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A Short Synthesis of Bisabolane Sesquiterpenes

A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by add...

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Detalles Bibliográficos
Autores principales: Du, Zhen-Ting, Zheng, Shuai, Chen, Gang, Lv, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264776/
https://www.ncbi.nlm.nih.gov/pubmed/21931286
http://dx.doi.org/10.3390/molecules16098053
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author Du, Zhen-Ting
Zheng, Shuai
Chen, Gang
Lv, Dong
author_facet Du, Zhen-Ting
Zheng, Shuai
Chen, Gang
Lv, Dong
author_sort Du, Zhen-Ting
collection PubMed
description A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
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spelling pubmed-62647762018-12-10 A Short Synthesis of Bisabolane Sesquiterpenes Du, Zhen-Ting Zheng, Shuai Chen, Gang Lv, Dong Molecules Article A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes. MDPI 2011-09-19 /pmc/articles/PMC6264776/ /pubmed/21931286 http://dx.doi.org/10.3390/molecules16098053 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Du, Zhen-Ting
Zheng, Shuai
Chen, Gang
Lv, Dong
A Short Synthesis of Bisabolane Sesquiterpenes
title A Short Synthesis of Bisabolane Sesquiterpenes
title_full A Short Synthesis of Bisabolane Sesquiterpenes
title_fullStr A Short Synthesis of Bisabolane Sesquiterpenes
title_full_unstemmed A Short Synthesis of Bisabolane Sesquiterpenes
title_short A Short Synthesis of Bisabolane Sesquiterpenes
title_sort short synthesis of bisabolane sesquiterpenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264776/
https://www.ncbi.nlm.nih.gov/pubmed/21931286
http://dx.doi.org/10.3390/molecules16098053
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