Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent cell death events in the body. Here, we present an approach for unbiased determination of the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types. The method is...

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Detalles Bibliográficos
Autores principales: Moss, Joshua, Magenheim, Judith, Neiman, Daniel, Zemmour, Hai, Loyfer, Netanel, Korach, Amit, Samet, Yaacov, Maoz, Myriam, Druid, Henrik, Arner, Peter, Fu, Keng-Yeh, Kiss, Endre, Spalding, Kirsty L., Landesberg, Giora, Zick, Aviad, Grinshpun, Albert, Shapiro, A. M. James, Grompe, Markus, Wittenberg, Avigail Dreazan, Glaser, Benjamin, Shemer, Ruth, Kaplan, Tommy, Dor, Yuval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265251/
https://www.ncbi.nlm.nih.gov/pubmed/30498206
http://dx.doi.org/10.1038/s41467-018-07466-6

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