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A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265262/ https://www.ncbi.nlm.nih.gov/pubmed/30140036 http://dx.doi.org/10.1038/s41379-018-0110-y |
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author | Rindi, Guido Klimstra, David S. Abedi-Ardekani, Behnoush Asa, Sylvia L. Bosman, Frederik T. Brambilla, Elisabeth Busam, Klaus J. de Krijger, Ronald R. Dietel, Manfred El-Naggar, Adel K. Fernandez-Cuesta, Lynnette Klöppel, Günter McCluggage, W. Glenn Moch, Holger Ohgaki, Hiroko Rakha, Emad A. Reed, Nicholas S. Rous, Brian A. Sasano, Hironobu Scarpa, Aldo Scoazec, Jean-Yves Travis, William D. Tallini, Giovanni Trouillas, Jacqueline van Krieken, J. Han Cree, Ian A. |
author_facet | Rindi, Guido Klimstra, David S. Abedi-Ardekani, Behnoush Asa, Sylvia L. Bosman, Frederik T. Brambilla, Elisabeth Busam, Klaus J. de Krijger, Ronald R. Dietel, Manfred El-Naggar, Adel K. Fernandez-Cuesta, Lynnette Klöppel, Günter McCluggage, W. Glenn Moch, Holger Ohgaki, Hiroko Rakha, Emad A. Reed, Nicholas S. Rous, Brian A. Sasano, Hironobu Scarpa, Aldo Scoazec, Jean-Yves Travis, William D. Tallini, Giovanni Trouillas, Jacqueline van Krieken, J. Han Cree, Ian A. |
author_sort | Rindi, Guido |
collection | PubMed |
description | The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classification suggested here is intended to allow pathologists and clinicians to manage their patients with NENs consistently, while acknowledging organ-specific differences in classification criteria, tumor biology, and prognostic factors. The classification suggested is based on a consensus conference held at the International Agency for Research on Cancer (IARC) in November 2017 and subsequent discussion with additional experts. The key feature of the new classification is a distinction between differentiated neuroendocrine tumors (NETs), also designated carcinoid tumors in some systems, and poorly differentiated NECs, as they both share common expression of neuroendocrine markers. This dichotomous morphological subdivision into NETs and NECs is supported by genetic evidence at specific anatomic sites as well as clinical, epidemiologic, histologic, and prognostic differences. In many organ systems, NETs are graded as G1, G2, or G3 based on mitotic count and/or Ki-67 labeling index, and/or the presence of necrosis; NECs are considered high grade by definition. We believe this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically. |
format | Online Article Text |
id | pubmed-6265262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-62652622018-12-03 A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal Rindi, Guido Klimstra, David S. Abedi-Ardekani, Behnoush Asa, Sylvia L. Bosman, Frederik T. Brambilla, Elisabeth Busam, Klaus J. de Krijger, Ronald R. Dietel, Manfred El-Naggar, Adel K. Fernandez-Cuesta, Lynnette Klöppel, Günter McCluggage, W. Glenn Moch, Holger Ohgaki, Hiroko Rakha, Emad A. Reed, Nicholas S. Rous, Brian A. Sasano, Hironobu Scarpa, Aldo Scoazec, Jean-Yves Travis, William D. Tallini, Giovanni Trouillas, Jacqueline van Krieken, J. Han Cree, Ian A. Mod Pathol Article The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classification suggested here is intended to allow pathologists and clinicians to manage their patients with NENs consistently, while acknowledging organ-specific differences in classification criteria, tumor biology, and prognostic factors. The classification suggested is based on a consensus conference held at the International Agency for Research on Cancer (IARC) in November 2017 and subsequent discussion with additional experts. The key feature of the new classification is a distinction between differentiated neuroendocrine tumors (NETs), also designated carcinoid tumors in some systems, and poorly differentiated NECs, as they both share common expression of neuroendocrine markers. This dichotomous morphological subdivision into NETs and NECs is supported by genetic evidence at specific anatomic sites as well as clinical, epidemiologic, histologic, and prognostic differences. In many organ systems, NETs are graded as G1, G2, or G3 based on mitotic count and/or Ki-67 labeling index, and/or the presence of necrosis; NECs are considered high grade by definition. We believe this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically. Nature Publishing Group US 2018-08-23 2018 /pmc/articles/PMC6265262/ /pubmed/30140036 http://dx.doi.org/10.1038/s41379-018-0110-y Text en © United States & Canadian Academy of Pathology 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Rindi, Guido Klimstra, David S. Abedi-Ardekani, Behnoush Asa, Sylvia L. Bosman, Frederik T. Brambilla, Elisabeth Busam, Klaus J. de Krijger, Ronald R. Dietel, Manfred El-Naggar, Adel K. Fernandez-Cuesta, Lynnette Klöppel, Günter McCluggage, W. Glenn Moch, Holger Ohgaki, Hiroko Rakha, Emad A. Reed, Nicholas S. Rous, Brian A. Sasano, Hironobu Scarpa, Aldo Scoazec, Jean-Yves Travis, William D. Tallini, Giovanni Trouillas, Jacqueline van Krieken, J. Han Cree, Ian A. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title | A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title_full | A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title_fullStr | A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title_full_unstemmed | A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title_short | A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal |
title_sort | common classification framework for neuroendocrine neoplasms: an international agency for research on cancer (iarc) and world health organization (who) expert consensus proposal |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265262/ https://www.ncbi.nlm.nih.gov/pubmed/30140036 http://dx.doi.org/10.1038/s41379-018-0110-y |
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