DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling

Autophagy is a highly regulated evolutionarily conserved metabolic process induced by stress and energy deprivation. Here, we show that DNA polymerase gamma (Polγ) deficiency activates a selective prosurvival autophagic response via mitochondria-mediated reactive oxygen species (ROS) signaling and t...

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Detalles Bibliográficos
Autores principales: Dhar, Sanjit K., Bakthavatchalu, Vasudevan, Dhar, Bithika, Chen, Jing, Tadahide, Izumi, Zhu, Haining, Gao, Tianyan, St. Clair, Daret K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265263/
https://www.ncbi.nlm.nih.gov/pubmed/30038268
http://dx.doi.org/10.1038/s41388-018-0404-z

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