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Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer

BACKGROUND: The IDF-11774, a novel clinical candidate for cancer therapy, targets HSP70 and inhibits mitochondrial respiration, resulting in the activation of AMPK and reduction in HIF-1α accumulation. METHODS: To identify genes that have synthetic lethality to IDF-11774, RNA interference screening...

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Detalles Bibliográficos
Autores principales:	Kim, Bo-Kyung, Nam, Soon Woo, Min, Byung Soh, Ban, Hyun Seung, Paik, Soonmyung, Lee, Kyeong, Im, Joo-Young, Lee, Youngjoo, Park, Joon-Tae, Kim, Seon-Young, Kim, Mirang, Lee, Hongsub, Won, Misun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265273/ https://www.ncbi.nlm.nih.gov/pubmed/30420612 http://dx.doi.org/10.1038/s41416-018-0289-1

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