Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

BACKGROUND: Cytidine deaminase (CDA) plays a crucial role in the degradation of gemcitabine. In our previous retrospective study, CDA enzymatic activity was the strongest prognostic biomarker of the activity and efficacy of platinum/gemcitabine combinations. The aim of this prospective study was to...

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Detalles Bibliográficos
Autores principales: Tibaldi, Carmelo, Camerini, Andrea, Tiseo, Marcello, Mazzoni, Francesca, Barbieri, Fausto, Vittimberga, Isabella, Brighenti, Matteo, Boni, Luca, Baldini, Editta, Gilli, Annalisa, Honeywell, Richard, Chartoire, Myriam, Peters, Godefridus J., Giovannetti, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265283/
https://www.ncbi.nlm.nih.gov/pubmed/30405211
http://dx.doi.org/10.1038/s41416-018-0307-3

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