Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53’s invasive/migratory gain-o...

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Detalles Bibliográficos
Autores principales: Novo, David, Heath, Nikki, Mitchell, Louise, Caligiuri, Giuseppina, MacFarlane, Amanda, Reijmer, Dide, Charlton, Laura, Knight, John, Calka, Monika, McGhee, Ewan, Dornier, Emmanuel, Sumpton, David, Mason, Susan, Echard, Arnaud, Klinkert, Kerstin, Secklehner, Judith, Kruiswijk, Flore, Vousden, Karen, Macpherson, Iain R., Blyth, Karen, Bailey, Peter, Yin, Huabing, Carlin, Leo M., Morton, Jennifer, Zanivan, Sara, Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265295/
https://www.ncbi.nlm.nih.gov/pubmed/30498210
http://dx.doi.org/10.1038/s41467-018-07339-y

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