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Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

Membrane proteins are universal signal decoders. The helical transmembrane segments of these proteins play central roles in sensory transduction, yet the mechanistic contributions of secondary structure remain unresolved. To investigate the role of main-chain hydrogen bonding on transmembrane functi...

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Detalles Bibliográficos
Autores principales:	Infield, Daniel T., Matulef, Kimberly, Galpin, Jason D., Lam, Kin, Tajkhorshid, Emad, Ahern, Christopher A., Valiyaveetil, Francis I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265297/ https://www.ncbi.nlm.nih.gov/pubmed/30498243 http://dx.doi.org/10.1038/s41467-018-07477-3

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