Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate

Lysine degradation has remained elusive in many organisms including Escherichia coli. Here we report catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates. We show that CsiD acts as an α-ketoglutarate-dependent dioxygenase catalysing hydroxylation...

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Detalles Bibliográficos
Autores principales: Knorr, Sebastian, Sinn, Malte, Galetskiy, Dmitry, Williams, Rhys M., Wang, Changhao, Müller, Nicolai, Mayans, Olga, Schleheck, David, Hartig, Jörg S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265302/
https://www.ncbi.nlm.nih.gov/pubmed/30498244
http://dx.doi.org/10.1038/s41467-018-07563-6

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