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Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion

An enhanced sense of prosthesis ownership may be the key for higher amputees’ quality of life. In this study in 28 healthy subjects, neuronavigated intermittent Theta Burst Stimulation (iTBS) delivered over the right ventral premotor cortex or inferior parietal lobule has been tested, compared to sh...

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Autores principales: Mioli, Alessandro, D’Alonzo, Marco, Pellegrino, Giovanni, Formica, Domenico, Di Pino, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265367/
https://www.ncbi.nlm.nih.gov/pubmed/30532689
http://dx.doi.org/10.3389/fnins.2018.00870
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author Mioli, Alessandro
D’Alonzo, Marco
Pellegrino, Giovanni
Formica, Domenico
Di Pino, Giovanni
author_facet Mioli, Alessandro
D’Alonzo, Marco
Pellegrino, Giovanni
Formica, Domenico
Di Pino, Giovanni
author_sort Mioli, Alessandro
collection PubMed
description An enhanced sense of prosthesis ownership may be the key for higher amputees’ quality of life. In this study in 28 healthy subjects, neuronavigated intermittent Theta Burst Stimulation (iTBS) delivered over the right ventral premotor cortex or inferior parietal lobule has been tested, compared to sham stimulation, to enhance embodiment in the rubber hand illusion paradigm. Neuromodulation of both areas did not result in an enhancement of embodiment, as assessed by the results collected from a self-evaluation questionnaire for the extent of self-attribution of the rubber hand and proprioceptive drift. In all cases, the difference between synchronous and asynchronous stroking confirms the successful induction of the illusion. It may be speculated that the low consistency of iTBS over brain regions other than primary motor cortex may account for the absence of effect, suggesting to test other neuromodulating techniques, acting on cortical networks different from the ones sensitive to iTBS to enhance artificial hand embodiment.
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spelling pubmed-62653672018-12-07 Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion Mioli, Alessandro D’Alonzo, Marco Pellegrino, Giovanni Formica, Domenico Di Pino, Giovanni Front Neurosci Neuroscience An enhanced sense of prosthesis ownership may be the key for higher amputees’ quality of life. In this study in 28 healthy subjects, neuronavigated intermittent Theta Burst Stimulation (iTBS) delivered over the right ventral premotor cortex or inferior parietal lobule has been tested, compared to sham stimulation, to enhance embodiment in the rubber hand illusion paradigm. Neuromodulation of both areas did not result in an enhancement of embodiment, as assessed by the results collected from a self-evaluation questionnaire for the extent of self-attribution of the rubber hand and proprioceptive drift. In all cases, the difference between synchronous and asynchronous stroking confirms the successful induction of the illusion. It may be speculated that the low consistency of iTBS over brain regions other than primary motor cortex may account for the absence of effect, suggesting to test other neuromodulating techniques, acting on cortical networks different from the ones sensitive to iTBS to enhance artificial hand embodiment. Frontiers Media S.A. 2018-11-23 /pmc/articles/PMC6265367/ /pubmed/30532689 http://dx.doi.org/10.3389/fnins.2018.00870 Text en Copyright © 2018 Mioli, D’Alonzo, Pellegrino, Formica and Di Pino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mioli, Alessandro
D’Alonzo, Marco
Pellegrino, Giovanni
Formica, Domenico
Di Pino, Giovanni
Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title_full Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title_fullStr Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title_full_unstemmed Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title_short Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion
title_sort intermittent theta burst stimulation over ventral premotor cortex or inferior parietal lobule does not enhance the rubber hand illusion
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265367/
https://www.ncbi.nlm.nih.gov/pubmed/30532689
http://dx.doi.org/10.3389/fnins.2018.00870
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