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The bacterial Mre11–Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions

The Mre11–Rad50 complex is a DNA double-strand break sensor that cleaves blocked DNA ends and hairpins by an ATP-dependent endo/exonuclease activity for subsequent repair. For that, Mre11–Rad50 complexes, including the Escherichia coli homolog SbcCD, can endonucleolytically cleave one or both strand...

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Detalles Bibliográficos
Autores principales:	Saathoff, Jan-Hinnerk, Käshammer, Lisa, Lammens, Katja, Byrne, Robert Thomas, Hopfner, Karl-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265447/ https://www.ncbi.nlm.nih.gov/pubmed/30277537 http://dx.doi.org/10.1093/nar/gky878

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