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Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway

DNA-damage tolerance protects cells via at least two sub-pathways regulated by proliferating cell nuclear antigen (PCNA) ubiquitination in eukaryotes: translesion DNA synthesis (TLS) and template switching (TS), which are stimulated by mono- and polyubiquitination, respectively. However, how cells c...

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Detalles Bibliográficos
Autores principales:	Masuda, Yuji, Mitsuyuki, Satoshi, Kanao, Rie, Hishiki, Asami, Hashimoto, Hiroshi, Masutani, Chikahide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265450/ https://www.ncbi.nlm.nih.gov/pubmed/30335157 http://dx.doi.org/10.1093/nar/gky943

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