Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment

The gene encoding the kinase Mnk2 (MKNK2) is alternatively spliced to produce two isoforms—Mnk2a and Mnk2b. We previously showed that Mnk2a is downregulated in several types of cancer and acts as a tumor suppressor by activation of the p38–MAPK stress pathway, inducing apoptosis. Moreover, Mnk2a ove...

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Detalles Bibliográficos
Autores principales: Mogilevsky, Maxim, Shimshon, Odelia, Kumar, Saran, Mogilevsky, Adi, Keshet, Eli, Yavin, Eylon, Heyd, Florian, Karni, Rotem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265459/
https://www.ncbi.nlm.nih.gov/pubmed/30329087
http://dx.doi.org/10.1093/nar/gky921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265459/
https://www.ncbi.nlm.nih.gov/pubmed/30329087
http://dx.doi.org/10.1093/nar/gky921

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