Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin–antitoxin system: targeting a tRNase to tackle mycobacterial adaptation

Toxin–antitoxin (TA) systems are involved in diverse physiological processes in prokaryotes, but their exact role in Mycobacterium tuberculosis (Mtb) virulence and in vivo stress adaptation has not been extensively studied. Here, we demonstrate that the VapBC11 TA module is essential for Mtb to esta...

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Detalles Bibliográficos
Autores principales: Deep, Amar, Tiwari, Prabhakar, Agarwal, Sakshi, Kaundal, Soni, Kidwai, Saqib, Singh, Ramandeep, Thakur, Krishan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265470/
https://www.ncbi.nlm.nih.gov/pubmed/30329074
http://dx.doi.org/10.1093/nar/gky924

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