Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (...

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Detalles Bibliográficos
Autores principales: van Welsem, Tibor, Korthout, Tessy, Ekkebus, Reggy, Morais, Dominique, Molenaar, Thom M, van Harten, Kirsten, Poramba-Liyanage, Deepani W, Sun, Su Ming, Lenstra, Tineke L, Srivas, Rohith, Ideker, Trey, Holstege, Frank C P, van Attikum, Haico, El Oualid, Farid, Ovaa, Huib, Stulemeijer, Iris J E, Vlaming, Hanneke, van Leeuwen, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265471/
https://www.ncbi.nlm.nih.gov/pubmed/30203048
http://dx.doi.org/10.1093/nar/gky801

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