Monitored eCLIP: high accuracy mapping of RNA-protein interactions

CLIP-seq methods provide transcriptome-wide snapshots of RNA-protein interactions in live cells. Reverse transcriptases stopping at cross-linked nucleotides sign for RNA-protein binding sites. Reading through cross-linked positions results in false binding site assignments. In the ‘monitored enhance...

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Detalles Bibliográficos
Autores principales: Hocq, Rémi, Paternina, Janio, Alasseur, Quentin, Genovesio, Auguste, Le Hir, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265473/
https://www.ncbi.nlm.nih.gov/pubmed/30252095
http://dx.doi.org/10.1093/nar/gky858

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