Analysis of Survival and of Time Until Recurrence of Disease of Patients With Papillary Thyroid Carcinoma–Multivariant Analysis

BACKGROUND: We examined survival and time until recurrence of disease by multivariant analysis in patients treated for papillary thyroid carcinoma (PTC). PATIENTS AND METHODS: In the period from January 2003 to January 2018, we analyzed 102 patients with PTC in Public Health Institution–Hospital “Sveti Vracevi” in Bijeljina. Survival and time until recurrence of the disease were analyzed using patients’ general data and factors based on preoperative, intraoperative and postoperative examinations. Many prognostic factors were analyzed together; the AGES prognostic score, consisting of age, grade, extent and size, and the AMES prognostic score, consisting of age, metastases, extent and size. RESULTS: We analyzed 102 patients with PTC. Out of these 87 patients had AGES p.s ≤ 3.99 and 15 patients had AGES p.s> 4. The survival of patients was affected by the presence of distant metastases at the time of diagnosis p = 0.00109 and age p = 0.0436. Recurrence of the disease was recorded in 14 patients. Most patients had recurrence of the disease in the first 5 years after initial surgery. Analyzing the time until recurrence, we concluded that, statistically speaking, AGES p.s> 4 affect recurrence of the disease p = 0.0355 in a significant way, while distant metastases affect it in a very significant way (p = 0.008). CONCLUSIONS: Prognostic factors of papillary thyroid carcinoma can be divided into 4 categories, patients’ general data and factors based on preoperative, intraoperative and postoperative examinations.