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Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions

Cell‐based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre‐clinical and small pilot clinical studies showed promising effects of cell therapy in peripheral artery disease and chron...

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Autores principales: Teraa, Martin, Gremmels, Hendrik, Wijnand, Joep G. J., Verhaar, Marianne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265636/
https://www.ncbi.nlm.nih.gov/pubmed/30070050
http://dx.doi.org/10.1002/sctm.18-0025
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author Teraa, Martin
Gremmels, Hendrik
Wijnand, Joep G. J.
Verhaar, Marianne C.
author_facet Teraa, Martin
Gremmels, Hendrik
Wijnand, Joep G. J.
Verhaar, Marianne C.
author_sort Teraa, Martin
collection PubMed
description Cell‐based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre‐clinical and small pilot clinical studies showed promising effects of cell therapy in peripheral artery disease and chronic limb‐threatening ischemia in particular. However, these promising results were not corroborated in larger high quality blinded randomized trials. This has led to a shift of the field towards more sophisticated cell products, especially mesenchymal stromal cells. Mesenchymal stromal cells have some important benefits, making these cells ideal for regenerative medicine, e.g., potential for allogeneic application, loss of disease‐mediated cell dysfunction, reduced production costs, off‐the‐shelf availability. Future high quality and large clinical studies have to prove the efficacy of mesenchymal stromal cells in the treatment of peripheral artery disease. Stem Cells Translational Medicine 2018;7:842–846
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spelling pubmed-62656362018-12-05 Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions Teraa, Martin Gremmels, Hendrik Wijnand, Joep G. J. Verhaar, Marianne C. Stem Cells Transl Med Perspectives Cell‐based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre‐clinical and small pilot clinical studies showed promising effects of cell therapy in peripheral artery disease and chronic limb‐threatening ischemia in particular. However, these promising results were not corroborated in larger high quality blinded randomized trials. This has led to a shift of the field towards more sophisticated cell products, especially mesenchymal stromal cells. Mesenchymal stromal cells have some important benefits, making these cells ideal for regenerative medicine, e.g., potential for allogeneic application, loss of disease‐mediated cell dysfunction, reduced production costs, off‐the‐shelf availability. Future high quality and large clinical studies have to prove the efficacy of mesenchymal stromal cells in the treatment of peripheral artery disease. Stem Cells Translational Medicine 2018;7:842–846 John Wiley & Sons, Inc. 2018-08-01 /pmc/articles/PMC6265636/ /pubmed/30070050 http://dx.doi.org/10.1002/sctm.18-0025 Text en © 2018 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Perspectives
Teraa, Martin
Gremmels, Hendrik
Wijnand, Joep G. J.
Verhaar, Marianne C.
Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title_full Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title_fullStr Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title_full_unstemmed Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title_short Cell Therapy for Chronic Limb‐Threatening Ischemia: Current Evidence and Future Directions
title_sort cell therapy for chronic limb‐threatening ischemia: current evidence and future directions
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265636/
https://www.ncbi.nlm.nih.gov/pubmed/30070050
http://dx.doi.org/10.1002/sctm.18-0025
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