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Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia

In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration an...

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Autores principales: Pallarès, Victor, Hoyos, Montserrat, Chillón, M. Carmen, Barragán, Eva, Prieto Conde, M. Isabel, Llop, Marta, Falgàs, Aïda, Céspedes, María Virtudes, Montesinos, Pau, Nomdedeu, Josep F., Brunet, Salut, Sanz, Miguel Ángel, González-Díaz, Marcos, Sierra, Jorge, Mangues, Ramon, Casanova, Isolda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265715/
https://www.ncbi.nlm.nih.gov/pubmed/30428571
http://dx.doi.org/10.3390/cancers10110436
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author Pallarès, Victor
Hoyos, Montserrat
Chillón, M. Carmen
Barragán, Eva
Prieto Conde, M. Isabel
Llop, Marta
Falgàs, Aïda
Céspedes, María Virtudes
Montesinos, Pau
Nomdedeu, Josep F.
Brunet, Salut
Sanz, Miguel Ángel
González-Díaz, Marcos
Sierra, Jorge
Mangues, Ramon
Casanova, Isolda
author_facet Pallarès, Victor
Hoyos, Montserrat
Chillón, M. Carmen
Barragán, Eva
Prieto Conde, M. Isabel
Llop, Marta
Falgàs, Aïda
Céspedes, María Virtudes
Montesinos, Pau
Nomdedeu, Josep F.
Brunet, Salut
Sanz, Miguel Ángel
González-Díaz, Marcos
Sierra, Jorge
Mangues, Ramon
Casanova, Isolda
author_sort Pallarès, Victor
collection PubMed
description In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN and SRC gene expression in a cohort of 324 patients, adults up to the age of 70, classified in the IR-AML cytogenetic group. Univariate and multivariate analyses showed that PTK2B, LYN and PTK2 gene expression are independent prognostic factors in IR-AML patients. PTK2B and LYN identify a patient subgroup with good prognosis within the cohort with non-favorable FLT3/NPM1 combined mutations. In contrast, PTK2 identifies a patient subgroup with poor prognosis within the worst prognosis cohort who display non-favorable FLT3/NPM1 combined mutations and underexpression of PTK2B or LYN. The combined use of these markers can refine the highly heterogeneous intermediate-risk subgroup of AML patients, and allow the development of risk-adapted post-remission chemotherapy protocols to improve their response to treatment.
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spelling pubmed-62657152018-12-03 Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia Pallarès, Victor Hoyos, Montserrat Chillón, M. Carmen Barragán, Eva Prieto Conde, M. Isabel Llop, Marta Falgàs, Aïda Céspedes, María Virtudes Montesinos, Pau Nomdedeu, Josep F. Brunet, Salut Sanz, Miguel Ángel González-Díaz, Marcos Sierra, Jorge Mangues, Ramon Casanova, Isolda Cancers (Basel) Article In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN and SRC gene expression in a cohort of 324 patients, adults up to the age of 70, classified in the IR-AML cytogenetic group. Univariate and multivariate analyses showed that PTK2B, LYN and PTK2 gene expression are independent prognostic factors in IR-AML patients. PTK2B and LYN identify a patient subgroup with good prognosis within the cohort with non-favorable FLT3/NPM1 combined mutations. In contrast, PTK2 identifies a patient subgroup with poor prognosis within the worst prognosis cohort who display non-favorable FLT3/NPM1 combined mutations and underexpression of PTK2B or LYN. The combined use of these markers can refine the highly heterogeneous intermediate-risk subgroup of AML patients, and allow the development of risk-adapted post-remission chemotherapy protocols to improve their response to treatment. MDPI 2018-11-13 /pmc/articles/PMC6265715/ /pubmed/30428571 http://dx.doi.org/10.3390/cancers10110436 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pallarès, Victor
Hoyos, Montserrat
Chillón, M. Carmen
Barragán, Eva
Prieto Conde, M. Isabel
Llop, Marta
Falgàs, Aïda
Céspedes, María Virtudes
Montesinos, Pau
Nomdedeu, Josep F.
Brunet, Salut
Sanz, Miguel Ángel
González-Díaz, Marcos
Sierra, Jorge
Mangues, Ramon
Casanova, Isolda
Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title_full Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title_fullStr Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title_full_unstemmed Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title_short Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia
title_sort focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265715/
https://www.ncbi.nlm.nih.gov/pubmed/30428571
http://dx.doi.org/10.3390/cancers10110436
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