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Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265732/ https://www.ncbi.nlm.nih.gov/pubmed/30424533 http://dx.doi.org/10.3390/nu10111738 |
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author | Chakrabarti, Subhadeep Guha, Snigdha Majumder, Kaustav |
author_facet | Chakrabarti, Subhadeep Guha, Snigdha Majumder, Kaustav |
author_sort | Chakrabarti, Subhadeep |
collection | PubMed |
description | Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment. |
format | Online Article Text |
id | pubmed-6265732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62657322018-12-06 Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities Chakrabarti, Subhadeep Guha, Snigdha Majumder, Kaustav Nutrients Review Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment. MDPI 2018-11-12 /pmc/articles/PMC6265732/ /pubmed/30424533 http://dx.doi.org/10.3390/nu10111738 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chakrabarti, Subhadeep Guha, Snigdha Majumder, Kaustav Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title | Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title_full | Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title_fullStr | Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title_full_unstemmed | Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title_short | Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities |
title_sort | food-derived bioactive peptides in human health: challenges and opportunities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265732/ https://www.ncbi.nlm.nih.gov/pubmed/30424533 http://dx.doi.org/10.3390/nu10111738 |
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