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Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Subhadeep, Guha, Snigdha, Majumder, Kaustav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265732/
https://www.ncbi.nlm.nih.gov/pubmed/30424533
http://dx.doi.org/10.3390/nu10111738
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author Chakrabarti, Subhadeep
Guha, Snigdha
Majumder, Kaustav
author_facet Chakrabarti, Subhadeep
Guha, Snigdha
Majumder, Kaustav
author_sort Chakrabarti, Subhadeep
collection PubMed
description Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.
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spelling pubmed-62657322018-12-06 Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities Chakrabarti, Subhadeep Guha, Snigdha Majumder, Kaustav Nutrients Review Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment. MDPI 2018-11-12 /pmc/articles/PMC6265732/ /pubmed/30424533 http://dx.doi.org/10.3390/nu10111738 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chakrabarti, Subhadeep
Guha, Snigdha
Majumder, Kaustav
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title_full Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title_fullStr Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title_full_unstemmed Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title_short Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
title_sort food-derived bioactive peptides in human health: challenges and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265732/
https://www.ncbi.nlm.nih.gov/pubmed/30424533
http://dx.doi.org/10.3390/nu10111738
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