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Population-Based Linkage of Big Data in Dental Research

Population-based linkage of patient-level information opens new strategies for dental research to identify unknown correlations of diseases, prognostic factors, novel treatment concepts and evaluate healthcare systems. As clinical trials have become more complex and inefficient, register-based contr...

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Detalles Bibliográficos
Autores principales: Joda, Tim, Waltimo, Tuomas, Pauli-Magnus, Christiane, Probst-Hensch, Nicole, Zitzmann, Nicola U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265733/
https://www.ncbi.nlm.nih.gov/pubmed/30366416
http://dx.doi.org/10.3390/ijerph15112357
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author Joda, Tim
Waltimo, Tuomas
Pauli-Magnus, Christiane
Probst-Hensch, Nicole
Zitzmann, Nicola U.
author_facet Joda, Tim
Waltimo, Tuomas
Pauli-Magnus, Christiane
Probst-Hensch, Nicole
Zitzmann, Nicola U.
author_sort Joda, Tim
collection PubMed
description Population-based linkage of patient-level information opens new strategies for dental research to identify unknown correlations of diseases, prognostic factors, novel treatment concepts and evaluate healthcare systems. As clinical trials have become more complex and inefficient, register-based controlled (clinical) trials (RC(C)T) are a promising approach in dental research. RC(C)Ts provide comprehensive information on hard-to-reach populations, allow observations with minimal loss to follow-up, but require large sample sizes with generating high level of external validity. Collecting data is only valuable if this is done systematically according to harmonized and inter-linkable standards involving a universally accepted general patient consent. Secure data anonymization is crucial, but potential re-identification of individuals poses several challenges. Population-based linkage of big data is a game changer for epidemiological surveys in Public Health and will play a predominant role in future dental research by influencing healthcare services, research, education, biotechnology, insurance, social policy and governmental affairs.
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spelling pubmed-62657332018-12-15 Population-Based Linkage of Big Data in Dental Research Joda, Tim Waltimo, Tuomas Pauli-Magnus, Christiane Probst-Hensch, Nicole Zitzmann, Nicola U. Int J Environ Res Public Health Review Population-based linkage of patient-level information opens new strategies for dental research to identify unknown correlations of diseases, prognostic factors, novel treatment concepts and evaluate healthcare systems. As clinical trials have become more complex and inefficient, register-based controlled (clinical) trials (RC(C)T) are a promising approach in dental research. RC(C)Ts provide comprehensive information on hard-to-reach populations, allow observations with minimal loss to follow-up, but require large sample sizes with generating high level of external validity. Collecting data is only valuable if this is done systematically according to harmonized and inter-linkable standards involving a universally accepted general patient consent. Secure data anonymization is crucial, but potential re-identification of individuals poses several challenges. Population-based linkage of big data is a game changer for epidemiological surveys in Public Health and will play a predominant role in future dental research by influencing healthcare services, research, education, biotechnology, insurance, social policy and governmental affairs. MDPI 2018-10-25 2018-11 /pmc/articles/PMC6265733/ /pubmed/30366416 http://dx.doi.org/10.3390/ijerph15112357 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Joda, Tim
Waltimo, Tuomas
Pauli-Magnus, Christiane
Probst-Hensch, Nicole
Zitzmann, Nicola U.
Population-Based Linkage of Big Data in Dental Research
title Population-Based Linkage of Big Data in Dental Research
title_full Population-Based Linkage of Big Data in Dental Research
title_fullStr Population-Based Linkage of Big Data in Dental Research
title_full_unstemmed Population-Based Linkage of Big Data in Dental Research
title_short Population-Based Linkage of Big Data in Dental Research
title_sort population-based linkage of big data in dental research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265733/
https://www.ncbi.nlm.nih.gov/pubmed/30366416
http://dx.doi.org/10.3390/ijerph15112357
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